Methotrexate-induced cutaneous ulceration in 3 nonpsoriatic patients: Report of a rare side effect
نویسندگان
چکیده
H&E: hematoxylin-eosin stain MTX: methotrexate RA: rheumatoid arthritis INTRODUCTION Methotrexate (MTX) is a commonly prescribed medication in the treatment of autoimmune conditions such as rheumatoid arthritis (RA) and psoriasis. MTX is a folic acid analog and DNA synthesis inhibitor that competitively inhibits dihydrofolate reductase. Well-known side effects of MTX include diarrhea, nausea/vomiting, anorexia, stomatitis, fatigue, and malaise. Cutaneous ulceration is a less commonly described sign of MTX toxicity in patients with psoriasis. Reported risk factors include relatively high MTX dosage, renal impairment, concurrent nonsteroidal anti-inflammatory drugs, age older than 55, folate deficiency, low serum albumin, and drug interactions. MTX-induced cutaneous ulceration in nonpsoriatic patients is rare, with the first case reported in 1998. Since 2011, only 5 cases have been reported. In this case series, we report MTX-induced cutaneous ulceration in 3 nonpsoriatic patients.
منابع مشابه
Methotrexate-induced nonhealing cutaneous ulcers in a nonpsoriatic patient without pancytopenia
Methotrexate forms one of the main drugs in the pharmacological management of rheumatoid arthritis, psoriasis, and some neoplastic diseases. Methotrexate rarely causes cutaneous ulceration and most cases are reported in patients with psoriasis and have been accompanied by pancytopenia. The author here reports occurrence of multiple (two) cutaneous ulcers due to methotrexate in a nonpsoriatic pa...
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